Adult Leydig cell maintenance
نویسندگان
چکیده
منابع مشابه
Insights into the Development of the Adult Leydig Cell Lineage from Stem Leydig Cells
Adult Leydig cells (ALCs) are the steroidogenic cells in the testes that produce testosterone. ALCs develop postnatally from a pool of stem cells, referred to as stem Leydig cells (SLCs). SLCs are spindle-shaped cells that lack steroidogenic cell markers, including luteinizing hormone (LH) receptor and 3β-hydroxysteroid dehydrogenase. The commitment of SLCs into the progenitor Leydig cells (PLC...
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In humans, as in all mammalian males, Leydig cells are the main source of the androgenic hormone, testosterone, which is essential for male sexual differentiation, gamete production and maturation, and development of secondary sexual characteristics. In this chapter, the development, steroidogenic function, and regulation of human Leydig cells are summarized. Clinical aspects of androgen secret...
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ژورنال
عنوان ژورنال: Nature Reviews Urology
سال: 2016
ISSN: 1759-4812,1759-4820
DOI: 10.1038/nrurol.2016.51